Medical Gene Technology Unit

Leader: Ferenc Erdélyi


The Medical Gene Technology Unit (MGTU) is a professionally independent, financially self-managed research animal facility of the institute conducting animal- and gene technology service, research & development activity.

MGTU comprises a high-capacity "SPF-specified pathogen-free” research animal facility suitable for housing and breeding genetically modified mice (GM) mostly in individually ventilated cage-system and a "nearly-pathogen free" (MD-minimal disease) animal facility mostly used by the researchers; a conventional receiving quarantine station and a gene technology unit. The latter consists of a microinjection laboratory behind the SPF barrier, genotyping, and molecular biology laboratories.

MGTU’s diverse professional activity covers almost the full spectrum of animal gene technology.

It includes the export/import of genetically modified (GM) mice; rederivation of GM mouse lines by embryo transfer and in vitro fertilization (IVF) to eliminate potential pathogens; repopulation of full animal facilities by rederivation; the establishment, maintenance, breeding, and genetic crossing of GM colonies for the production of complex mouse models; archiving GM lines as frozen embryos and sperm; DNA-based genotyping. The Unit’s high priority activity is to produce genetically engineered mouse models using microinjection technology including DNA fragment-, modified BAC-, transposase- and CRISPR/Cas9 based techniques.

MGTU provides a full spectrum of animal- and gene technology services to the entire research community supporting academic basic research as well as applied research and development of the pharmaceutical industry.

This continuously improved high-value technology portfolio is not available elsewhere in the country.
Building on almost two decades of unique experience in Hungary, MGTU contributes to the most effective use of GA animal models by providing advice, theoretical and practical training to the research community.
Furthermore, giving educational lectures will help to understand the social benefits of using GA animal models and also increase its acceptance.


Excerpt from the Guidebook of the Institute 2015.

Members:

NamePosition
Ferenc ErdélyiHead of Unit
Katalin BartosekAnimal Technician
Balázs BecseyMGTU Guardian
Kálmán DanóAnimal Caretaker
Mária Geszlerné EcsediAnimal Technician
Józsefné HajduAnimal Technician
Tünde JuhászAnimal Caretaker
Viktória Kollár-VinceAnimal Caretaker
Pálma KunAnimal Caretaker
Adrienn MáthéAnimal Caretaker
Miklós MénessyAnimal Caretaker
Balázs SzikszaiAnimal Technician
Gergely SzőregiAnimal Technician
Miklós TóthaAnimal Caretaker
Tamás ZolczerSPF Guardian
Márta KovácsLaboratory Assistant
Katalin KovácsEmbryologist
Ágnes DobosGene Technologist
Zsuzsanna ErdélyiGene Technologist
Zita KisLaboratory Assistant
Zoltán MátéPhD Student