Molecular Cell Metabolism

Group 24
Leader: Balázs Gereben


Thyroid hormones (TH) are master regulators of cellular metabolism and proliferation and consequently exert a fundamental impact on brain development and function predominantly due to their impact on transcriptomic activity. The Laboratory aims to (i) identify and modulate cell-type specific molecular pathways responsible for the regulation of TH economy in the brain and coupled peripheries; (ii) translate these mechanisms to specific brain functions under physiological and pathophysiological conditions; (iii) develop transgenic approaches to assess and modulate cell-type specific TH action.

They combine molecular, cell biological, anatomical and transgenic techniques to study regulation and consequences of TH signalling. (1) They study the molecular regulation of deiodinase enzymes mediating TH metabolism with special respect to the complex and tight regulation of type 2 deiodinase (D2) to identify molecular elements and protein-protein interactions allowing the rapid regulation of D2 activity along the ubiquitin/proteasome pathway and its role in the generation of tissue-specific hypothyroidism. The studies also target the regulation of the D2-encoding dio2 gene during hypothalamic response to inflammation, a phenomenon they described as a component of the pathogenesis of the nonthyroidal illness syndrome. (2) They investigate the mechanisms and biological consequences of D2 and type 3 deiodinase (D3) mediated neuro-glial coupling of TH metabolism and its impact on the hypothalamo-pituitary-thyroid axis, on adult neurogenesis and aging. (3) The Laboratory is involved in the generation of transgenic mouse models for cell-type specific modulation and assessment of TH signalling and also aims to identify human markers representing tissue TH economy. This resulted in the generation and patenting of the Thyroid Hormone Action Indicator (THAI) Mouse, allowing tissue-specific assessment of TH action in vivo.


Excerpt from the Guidebook of the Institute 2015.

Grants:

  • EU H2020 “Thyrage” Grant Agreement 666869 Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
  • Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002) Cell-type specific assessment of thyroid hormone economy in neurosecretory neurons of live mice
  • NKFI 125247 National Research, Development and Innovation Office of Hungary
    Tissue specific assessment of medical therapy evoked alterations of thyroid hormone economy in rodents and humans

Lab members:

NamePosition
Balázs GerebenScientific Advisor, Group Leader
Andrea JuhászTechnician
Petra MohácsikAssociated Research Fellow
Kristóf RadaAssistant Research Fellow
Richárd SinkóPhD Student