Tudományos közlemények
Tudományos publikációk listája, amelyekben a viselkedési teszteket a Viselkedésvizsgálati Egységben végezték.
2024
The role of the GABAergic cells of the median raphe region in reinforcement-based learning.
Chaves T, Török B, Fazekas C, Correia P, Karailiev P, Oravcova H, Sipos E, Biró L, Haller J, Jezova D, Zelena D.
Sci Rep. 2024 Jan 12;14(1):1175. doi: 10.1038/s41598-024-51743-y.
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2023
P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse.
Huang L, Mut-Arbona P, Varga B, Török B, Brunner J, Arszovszki A, Iring A, Kisfali M, Vizi ES, Sperlágh B.
iScience 2023 Aug 7;26(9):107560. doi: 10.1016/j.isci.2023.107560.
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Fear memory recall involves hippocampal somatostatin interneurons.
Zichó K, Sos KE, Papp P, Barth AM, Misák E, Orosz Á, Mayer MI, Sebestény RZ, Nyiri G.
PLoS Biol. 2023 Jun 8;21(6):e3002154. doi: 10.1371/journal.pbio.3002154.
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Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets.
Biro L, Miskolczi C, Szebik H, Bruzsik B, Varga ZK, Szente L, Toth M, Halasz J, Mikics E.
Neurobiol Stress. 2023 May 29;25:100546. doi: 10.1016/j.ynstr.2023.100546.
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Dual role of the P2X7 receptor in dendritic outgrowth during physiological and pathological brain development
Mut-Arbona P, Huang L, Baranyi M, Tod P, Iring A, Calzaferri F, de Los Ríos C, Sperlágh B.
J Neurosci. 2023 Jan 27;JN-RM-0805-22. doi: 10.1523/JNEUROSCI.0805-22.2022.
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Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice
Szabó A, Farkas S, Fazekas C, Correia P, Chaves T, Sipos E, Makkai B, Török B, Zelena D.
Biomedicines. 2023 Jan 18;11(2):262. doi: 10.3390/biomedicines11020262.
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The effectiveness of extinction training in male rats: Temporal considerations and brain mechanisms
Correia P, Demeter K, Varga J, Urbán E, Török B, Balázsfi D, Bakos N, Haller J, Zelena D.
Behav Brain Res. 2023 Jan 4;441:114285. doi: 10.1016/j.bbr.2023.114285.
2022
Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer's Disease.
Várkonyi D, Török B, Sipos E, Fazekas CL, Bánrévi K, Correia P, Chaves T, Farkas S, Szabó A, Martínez-Bellver S, Hangya B, Zelena D.
Int J Mol Sci. 2022 Sep 16;23(18):10816. doi: 10.3390/ijms231810816.
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Median raphe region GABAergic neurons contribute to social interest in mouse.
Chaves T, Török B, Fazekas CL, Correia P, Sipos E, Várkonyi D, Hellinger Á, Erk D, Zelena D.
Life Sci. 2022 Jan 15;289:120223. doi: 10.1016/j.lfs.2021.120223.
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Elevated serum purine levels in schizophrenia: a reverse translational study to identify novel inflammatory biomarkers
Kristóf Z, Baranyi M, Tod P, Mut-Arbona P, Demeter K, Bitter I, Sperlágh B.
Int J Neuropsychopharmacol. 2022 Apr 20; doi: 10.1093/ijnp/pyac026
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Rescue of vasopressin synthesis in magnocellular neurons of the supraoptic nucleus normalises acute stress-induced adrenocorticotropin secretion and unmasks an effect on social behaviour in male vasopressin-deficient Brattleboro rats
Török B, Csikota P, Fodor A, Balázsfi D, Ferenczi S, Demeter K, Tóth ZE, Könczöl K, Perna JC, Farkas I, Kovács KJ, Haller J, Engelmann M, Zelena D.
Int J Mol Sci. 2022 Jan 25;23(3):1357. doi: 10.3390/ijms23031357.
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Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway
Szabó D, Tod P, Gölöncsér F, Román V, Lendvai B, Otrokocsi L, Sperlágh B.
Brain Behav Immun. 2022; doi: 10.1016/j.bbi.2022.01.015.
2021
Pharmacogenetic excitation of the median raphe region affects social and depressive-like behavior and core body temperature in male mice
Fazekas CL, Bellardie M, Török B, Sipos E, Tóth B, Baranyi M, Sperlágh B, Dobos-Kovács M, Chaillou E, Zelena D.
Life Sci. 2021; 286:120037. doi: 10.1016/j.lfs.2021.120037.
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Neurochemically distinct populations of the bed nucleus of stria terminalis modulate innate fear response to weak threat evoked by predator odor stimuli.
Bruzsik B, Biro L, Sárosdi KR, Zelena D, Sipos E, Szebik H, Török B, Mikics E, Tóth M.
Neurobiol Stress. 2021; 15:100415. doi: 10.1016/j.ynstr.2021.100415
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Ensemble averaging laser speckle contrast imaging: statistical model of improvement as function of static scatterers.
Földesy P, Siket M, Jánoki I, Demeter K, and Nagy Á.
Optics Express 2021 Aug. 29(18): 29366-29377
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Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice.
Bruzsik B, Biro L, Zelena D, Sipos E, Szebik H, Sárosdi KR, Horváth O, Farkas I, Csillag V, Finszter CK, Mikics É, Tóth M.
J Neurosci . 2021 Mar 3;41(9):1982-1995.
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Time varied illumination laser speckle contrast imaging
Siket M, Jánoki I, Demeter K, Szabó M, Földesy P.
Optics Letters 2021 Vol. 46, Issue 4, pp. 713-716
2020
Amyloid β Induces Interneuron-Specific Changes in the Hippocampus of APPNL-F Mice
Sós KE, Mayer MI, Takács VT, Major Á, Bardóczi Z, Béres BM, Széles T, Saito T, Saido TC, Mody I, Freund TF, Nyíri G.
PLoS One . 2020 May 29;15(5):e0233700.
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P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia
Calovi S, Mut-Arbona P, Tod P, Iring A, Nicke A, Mato S, Vizi ES, Tønnesen J, Sperlagh B.
Front Mol Neurosci . 2020 Nov 11;13:566251.
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Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder
Fazekas CL, Sipos E, Klaric T, Török B, Bellardie M, Erjave GN, Perkovic MN, Lauc G, Pivac N, Zelena D.
Stress. 2020 Nov;23(6):715-731.
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Acute blockade of NR2C/D subunit-containing N-methyl-D-aspartate receptors modifies sleep and neural oscillations in mice
Pálfi E, Lévay G, Czurkó A, Lendvai B, Kiss T.
J Sleep Res. 2020 Dec 13;e13257.
2019
Consequences of VGluT3 deficiency on learning and memory in mice.
Fazekas CL, Balázsfi D, Horváth HR, Balogh Z, Aliczki M, Puhova A, Balagova L, Chmelova M, Jezova D, Haller J, Zelena D.
Physiol Behav. 2019. 212:112688.
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Median raphe controls acquisition of negative experience in the mouse.
Szőnyi A, Zichó K, Barth AM, Gönczi RT, Schlingloff D, Török B, Sipos E, Major A, Bardóczi Z, Sos KE, Gulyás AI, Varga V, Zelena D, Freund TF, Nyiri G.
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Chronic Amyloid β Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via NLRP3
Fekete C, Vastagh C, Dénes Á, Hrabovszky E, Nyiri G, Kalló I, Liposits Z, Sárvári M.
Neuroscience. 2019; 405:35-46. doi: 10.1016/j.neuroscience.2018.02.046
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Brainstem nucleus incertus controls contextual memory formation.
Szőnyi A, Sós KE, Nyilas R, Schlingloff D, Domonkos A, Takács VT, Pósfai B, Hegedűs P, Priestley JB, Gundlach AL, Gulyás AI, Varga V, Losonczy A, Freund TF, Nyíri G.
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P2X7 Receptors Drive Poly(I:C) Induced Autism-like Behavior in Mice.
Horváth G, Otrokocsi L, Beko K, Baranyi M, Kittel Á, Fritz-Ruenes PA, Sperlágh B.
J Neurosci. 2019. 39(13):2542-2561.
2018
The swimming plus-maze test: a novel high-throughput model for assessment of anxiety-related behaviour in larval and juvenile zebrafish (Danio rerio).
Varga ZK, Zsigmond Á, Pejtsik D, Varga M, Demeter K, Mikics É, Haller J, Aliczki M.
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Enhanced innate fear and altered stress axis regulation in VGluT3 knockout mice.
Balázsfi D, Fodor A, Török B, Ferenczi S, Kovács KJ, Haller J, Zelena D.
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Differential Roles of the Two Raphe Nuclei in Amiable Social Behavior and Aggression - An Optogenetic Study.
Balázsfi D, Zelena D, Demeter K, Miskolczi C, Varga ZK, Nagyváradi Á, Nyíri G, Cserép C, Baranyi M, Sperlágh B, Haller J.
Front Behav Neurosci. 2018. 12:163.
2017
Median raphe region stimulation alone generates remote, but not recent fear memory traces.
Balázsfi DG, Zelena D, Farkas L, Demeter K, Barna I, Cserép C, Takács VT, Nyíri G, Gölöncsér F, Sperlágh B, Freund TF, Haller J.
PLoS One. 2017. 12(7):e0181264
2016
The prepulse inhibition deficit appearance is largely independent on the circadian cycle, body weight, and the gender of vasopressin deficient Brattleboro rat.
Fodor A, Klausz B, Tóth B, Zelena D.
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Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats.
Fodor A, Kovács KB, Balázsfi D, Klausz B, Pintér O, Demeter K, Daviu N, Rabasa C, Rotllant D, Nadal R, Zelena D.
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Possible contribution of epigenetic changes in the development of schizophrenia-like behavior in vasopressin-deficient Brattleboro rats.
Demeter K, Török B, Fodor A, Varga J, Ferenczi S, Kovács KJ, Eszik I, Szegedi V, Zelena D.