Central regulatory mechanisms of metabolism
With support of the European Framework Programmes (5-7), we have been collaborating with outstanding European research laboratories of this scientific field to elucidate novel neuronal and hormonal mechanisms that control metabolism centrally. These studies have explored several, new regulatory channels:
· Reinstatement of blunted leptin sensitivity during hedonic overeating by galanin receptor activation. (Prof. O. Almeida, Germany)
· Regulation of brown fat thermogenesis by hypothalamic dopamine signaling. The role and mechanism whereby MCH regulate POMC neuronal activity to induce hyperphagia, adiposity and glucose intolerance. (Prof. R. Nogueiras, Spain)
· Regulatory role of ghrelin receptor stimulation of the lateral parabrachial nucleus in increased food intake. Involvement of nicotinic ACh receptor signaling in regulation of ghrelin-induced food intake (Prof. S. Dickson, Sweden)
· Role of MCH 3 receptor signaling in midbrain dopamine neurons in increased motivation for food reward. Structural and functional characterization of orexin inputs of dopamine neurons of the VTA projecting to the nucleus accumbens and the medial prefrontal cortex. (Prof. R.A.H. Adan, the Netherlands)
T. Bake, M. V. Le May, C. E. Edvardsson, H. Vogel, U. Bergström, M. N. Albers, K. P. Skibicka, I. Farkas, Z. Liposits, and S. L. Dickson, “Ghrelin Receptor Stimulation of the Lateral Parabrachial Nucleus in Rats Increases Food Intake but not Food Motivation,” OBESITY, vol. 28, no. 8, pp. 1503–1511, 2020.
E. Leidmaa, M. Gazea, A. V. Patchev, A. Pissioti, N. C. Gassen, M. Kimura, Z. Liposits, I. Kallo, and O. F. X. Almeida, “Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus.,” ACTA PHYSIOLOGICA, vol. 228, no. 2, 2020.
C. Folgueira, D. Beiroa, B. Porteiro, M. Duquenne, E. Puighermanal, M. F. Fondevila, S. Barja-Fernández, R. Gallego, R. Hernández-Bautista, C. Castelao, A. Senra, P. Seoane, N. Gómez, P. Aguiar, D. Guallar, M. Fidalgo, A. Romero-Pico, R. Adan, C. Blouet, J. L. Labandeira-García, F. Jeanrenaud, I. Kallo, Z. Liposits, J. Salvador, V. Prevot, C. Dieguez, M. Lopez, E. Valjent, G. Frühbeck, L. M. Seoane, and R. Nogueiras, “Hypothalamic dopamine signaling regulates brown fat thermogenesis.,” NATURE METABOLISM, vol. 1, no. 8, pp. 811–829, 2019.
O. Al-Massadi, M. Quiñones, J. Clasadonte, R. H. Bautista, A. Romero-Picó, C. Folgueira, D. A. Morgan, I. Kalló, V. Heras, A. Senra, S. C. Funderburk, M. J. Krashes, Y. Souto, M. Fidalgo, S. Luquet, M. J. Chee, M. Imbernon, D. Beiroa, L. García-Caballero, R. Gallego, B. Y. H. Lam, G. Yeo, M. Lopez, Z. Liposits, K. Rahmouni, V. Prevot, C. Dieguez, and R. Nogueiras, “MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity and Glucose Intolerance.,” DIABETES, vol. 68, no. 12, pp. 2210–2222, 2019.
F. Anesten, A. Dalmau Gasull, J. E. Richard, I. Farkas, D. Mishra, L. Taing, F.-P. Zhang, M. Poutanen, V. Palsdottir, Z. Liposits, K. P. Skibicka, and J.-O. Jansson, “Interleukin-6 in the central amygdala is bioactive and co-localized with glucagon-like peptide-1 receptor,” JOURNAL OF NEUROENDOCRINOLOGY, vol. 31, no. 6, 2019.
Z. Péterfi, I. Farkas, R. G. P. Denis, E. Farkas, M. Uchigashima, T. Füzesi, M. Watanabe, R. M. Lechan, Z. Liposits, S. Luquet, and C. Fekete, “Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditure,” MOLECULAR METABOLISM, vol. 18, pp. 120–133, 2018.
M. Imbernon, E. Sanchez-Rebordelo, A. Romero-Pico, I. Kallo, M. Chee, B. Porteiro, O. Al-Massadi, C. Contreras, J. Ferno, A. Senra, R. Gallego, C. Folgueira, L. Seoane, M. van Gestel, R. Adan, Z. Liposits, C. Dieguez, M. Lopez, and R. Nogueiras, “Hypothalamic kappa opioid receptor mediates both diet- and MCH-induced liver damage through inflammation and ER stress.,” HEPATOLOGY, vol. 64, no. 4, pp. 1086–1104, 2016.
R. Pandit, A. Omrani, M. Luijendijk, V. de Vrind, R. A. Van, R. Ophuis, K. Garner, I. Kallo, A. Ghanem, Z. Liposits, K. Conzelmann, L. Vanderschuren, F. S. la, and R. Adan, “Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.,” NEUROPSYCHOPHARMACOLOGY, vol. 41, no. 9, pp. 2241–2251, 2016.
J. Richard, I. Farkas, F. Anesten, R. Anderberg, S. Dickson, F. Gribble, F. Reimann, J. Jansson, Z. Liposits, and K. Skibicka, “GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence.,” ENDOCRINOLOGY, vol. 155, no. 11, pp. 4356–4367, 2014.
M. Alvarez-Crespo, K. Skibicka, I. Farkas, C. Molnar, E. Egecioglu, E. Hrabovszky, Z. Liposits, and S. Dickson, “The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence,” PLOS ONE, vol. 7, no. 10, p. e46321, 2012.