All research areas

No results

Cortex-wide activation of VIP-expressing inhibitory neurons by reward and punishment

Cortex- wide activation of VIP- expressing inhibitory neurons by reward and punishment

Research 45-3

Research group: Biological Computation
Research 45-3

Research: Collaborations

Research group: Cellular Neuropharmacology

...about our contributions to the projects of other research groups

Research 44-3

Research group: Neuroimmunology Lab
Research 44-3

Research 25-1

Research group: Reproductive Neurobiology
Research 25-1

Research 102-1

Research group: Light Microscopy Center
Research 102-1

Research 103-2

Research group: Electron Microscopy Center
Research 103-2

3D two-photon imaging

Fast, two- photon imaging with three-dimensional scanning of spine, dendritic and neuronal assemblies in behaving animals

Research 45-2

Research group: Biological Computation
Research 45-2

Local connectivity of excitatory projection neurons in the basolateral amygdala

Basolateral amygdala is a complex cortical structure composed of three nuclei: lateral, basal and basomedial nucleus.

Thalamus and Stress

Research group: Thalamus Research

In this project we study the role of thalamus in stress induced behavioral alterations.

A novel midbrain-extended amygdala pathway controls defensive behavior

A novel research direction of our team is to unravel the circuit mechanisms underlying defensive behavior. 

Synaptic cannabinoid signaling

With our research activity we aim to contribute to the understanding of how distinct endocannabinoid-related signaling pathways regulate certain forms of synaptic plasticity.

Research 102-3

Research group: Light Microscopy Center
Research 102-3

Research 25-2

Research group: Reproductive Neurobiology
Research 25-2

Research 103-1

Research group: Electron Microscopy Center
Research 103-1

Human Thalamus

Research group: Thalamus Research

In this project, we study the synaptic organization of the human thalamus.

Development of methodology for cell-type-specific nanoscale molecular imaging in brain circuits

Development of methodology for cell-type-specific nanoscale molecular imaging in brain circuits

Research: current project

Research group: Cellular Neuropharmacology

…about the roles of small axons, whose size matches that of the majority cortical axons

 

In vivo network imaging

Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes

Thalamus and Motor Behavior

Research group: Thalamus Research

In this project we study the role of thalamus in motor learning.

Research 105-2

Research group: Cell Biology Unit
Research 105-2

In vitro measurement of spontaneous neuronal network activity

In vitro measurement of spontaneous neuronal network activity

Research 105-3

Research group: Cell Biology Unit
Research 105-3

Creating a molecular map of the neuronal surface

Research group: Cellular Neurophysiology

Determining the location and density of various voltage- and ligand-gated ion channels in defined subcellular compartments of hippocampal pyramidal cells, using quantitative LM and EM immunolocalization. Perform multi-compartmental modeling to generate functionally testable predictions of the functional consequences of specialized ion channel distributions. In vitro electrophysiology and imaging approaches are used to test the functional predictions of our models.

Microcircuit organization of the perisomatic inhibition in the medial prefrontal cortex

Prefrontal cortex plays a role in many higher order cognitive processes. 

Effect of endocrine disruptors on thyroid hormone homeostasis

Research group: Molecular Cell Metabolism

                                        

Schizophrenia

Schizophrenia is a complex neurodevelopmental disorder that affects approximately 0.5%–1% of the global population and is 1 of the top 10 global causes of disability.  Like most mental disorders, schizophrenia appears to be caused by a combination of genetic, environmental, and social risk factors linked to each other by epigenetic mechanisms regulating gene expression levels and molecular pathways. . Although the pathophysiology of schizophrenia is still not completely understood, there is a growing awareness that dysregulation of immune system components is fundamentally linked to the disorder.  

Project 3

Research group: Neuronal Signaling
Research 35-3

MPTP induced Pakinson model

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. 

Research 101-2

Research group: Virus Technology Unit
Research 101-2

Research 101-3

Research group: Virus Technology Unit
Research 101-3

Research 103-3

Research group: Electron Microscopy Center
Research 103-3

COVID-19

Active research and clinical experience have shown that the uncontrolled immune response to Sars-Cov-2 is characterized in many cases by a devastating cytokine storm (Chaolin Huang 2020). Morbidity and mortality are in part a consequence of this inflammatory response in the body (Ye Q 2020). The course of the disease is known to be more severe in pregnant women (Kathryn M Moore 2021), however, the effect of SARS-CoV-2 on the developing fetus is currently unclear. Case studies show that vertical transmission is rare, however, several studies support that placental and fetal infections may occur (Chen H 2020), (Dong L 2020), (Patanè L 2020). Several clinical manifestations of Covid-19 infection in the nervous system have also been reported recently (Desforges M. 2020), (Bohmwald K. 2018). 

Major depression

Depression - diagnosed as a condition lasting at least 2 weeks, with lethargy and/or loss of pleasure as the leading symptoms - is the most common psychiatric disorder in the world.

Project 1

Research group: Neuronal Signaling
Research 35-1

Research 107-2

Research group: Metabolic Phenotyping Unit
Research 107-2

Research: completed projects

Research group: Cellular Neuropharmacology

…about the cellular interface between DG and CA3 regions

Research 105-1

Research group: Cell Biology Unit
Research 105-1

Restoration of visual perception by 3D artifical photostimulation

Restoration of visual perception by 3D artifical photostimulation

Mechanisms underlying tissue hypothyroidism in the brain during thyroxine substitution therapy

Research group: Molecular Cell Metabolism

                                              

Autism spectrum disorder

ASD is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently, maternal viral infections during pregnancy and their immunological consequences have received particular interest in research as risk factors for neurodevelopmental disorders. 

Research 102-2

Research group: Light Microscopy Center
Research 102-2

Non-canonical forms of cannabinoid signaling

Non-canonical forms of cannabinoid signaling

Two-photon uncaging

High efficiency two-photon uncaging coupled by the correction of spontaneous hydrolysis

Mania model

Purinergic dysfunction are involved in the pathological process of mania and depression, but the essential association is not fully understood. The activation of the purinergic P2X7 receptor (P2X7R) plays a central role in inflammation, microglia activation and IL-1β release and activates NLRP3 inflammasome. We investigated whether the d-amphetamine (AMPH) has an inflammatory profile, and the P2X7R has an effect via IL-1β in this model.

Thalamus and Cortex

Research group: Thalamus Research

In this project we study the diversity of interactions between cortex and thalamus.

Research 101-1

Research group: Virus Technology Unit
Research 101-1

Revealing the cellular and synaptic mechanisms underlying the diverse firing properties of hippocampal pyramidal cells during behavior.

Research group: Cellular Neurophysiology

In vivo two-photon [Ca2+] imaging are performed in head-restrained mice while performing navigation in virtual reality to functionally characterize distinct pyramidal cells. This is followed by post hoc in vitro electrophysiological and anatomical experiments to reveal differences in intrinsic properties and synaptic innervation of the functionally characterized nerve cells.

Development of thyroid hormone gradients in the nervous system

Research group: Molecular Cell Metabolism

                                 

Research 25-3

Research group: Reproductive Neurobiology
Research 25-3

Research 44-1

Research group: Neuroimmunology Lab
Research 44-1

Project 2

Research group: Neuronal Signaling
Research 35-2

Revealing the molecular, structural and functional heterogeneity of cortical synapses

Research group: Cellular Neurophysiology

Determine the molecular specializations underlying the functional diversity of synapses, such as the probability and short-term plasticity of neurotransmitter release. In vitro electrophysiology, two-photon imaging, LM and EM immunolocalization are combined to address these issues.

Research 107-3

Research group: Metabolic Phenotyping Unit
Research 107-3

Research 107-1

Research group: Metabolic Phenotyping Unit
Research 107-1

Research 44-2

Research group: Neuroimmunology Lab
Research 44-2

Research 45-1

Research group: Biological Computation
Research 45-1